Injection Semaglutide
Semaglutide Injection Guide
Click to playThis guide walks you through the proper technique for administering subcutaneous injections for GLP-1 medications. If you’re unsure whether to inject in your thigh or abdomen, we’ve got you covered.
You’ll find a step-by-step breakdown, from preparing your medication to choosing the ideal injection site and ensuring a smooth, comfortable process. We’ll also cover dosing guidelines, site rotation strategies, and tips to reduce discomfort.
What’s Included in Your SkinnyRx Shipment
One or more vials of compounded Semaglutide
Subcutaneous needles for injection
Alcohol pads for proper site preparation
Before You Start
Check the Beyond Use Date (EXP) on your medication vial.
Verify that your syringe’s unit markings match your prescribed dosage.
Never use medication past its Beyond Use Date.
Regardless of the expiration date, vials should be discarded 28 days after the first use.
Semaglutide should not be used during pregnancy or breastfeeding. Let your provider know immediately if you’re planning pregnancy.
Wash Your Hands & Prepare the Injection Site
Start by washing your hands thoroughly. Always use a clean, flat surface to avoid contamination. Then, choose one of the recommended injection sites:
Fatty layer of the abdomen
Front or side of the thigh
Upper arm
Clean the selected area with an alcohol pad and let it dry completely. To prevent irritation or lumps, rotate your injection site each week.
Prepare the Medication
Wipe the top of the Semaglutide vial with a fresh alcohol pad.
Pull back the syringe plunger slightly to draw in a small amount of air.
Insert the needle into the vial and inject the air to make drawing the medication easier.
Invert the vial and withdraw the prescribed units of medication following the specific unit markings and instructions provided.
Remove air bubbles by gently tapping the syringe and pressing the plunger until a small drop appears at the needle tip.
Administer the Injection
Clean the injection site with an alcohol pad and let it dry.
Pinch a small fold of skin and insert the needle at a 90-degree angle until fully submerged.
Slowly and steadily press the plunger to inject the medication. Then, pull the syringe straight out of the skin. Remove the needle, then dispose of it safely in a sharps container.
If needed, apply gentle pressure with a cotton ball—do not rub.
Mild bleeding or minor bruising is normal and can be minimized by rotating sites and using proper technique. Persistent or painful swelling should be reported to us.
Best Practices
The medication should be kept in the refrigerator between 36°F and 46°F (2°C and 8°C), and never frozen. Let it come to room temperature before injecting if needed.
Inject Semaglutide just once a week, on the same day each week. If you need to change injection days, just make sure at least 48 hours has passed since your last injection.
If you miss a dose within 5 days, take it as soon as possible. If it’s close to your next dose, skip and resume your normal schedule.
If you accidentally touch the needle or spill the medication, dispose of contaminated supplies in a sharps container and never reuse needles or syringes—request replacements as needed.
